Search on: FORMYLTETRAHYDROFOLATE SYNTHETASE 
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Descriptor English:   Formate-Tetrahydrofolate Ligase 
Descriptor Spanish:   Formiato-Tetrahidrofolato Ligasa 
Descriptor Portuguese:   Formiato-Tetra-Hidrofolato Ligase 
Synonyms English:   Formate Tetrahydrofolate Ligase
Formylase, Tetrahydrofolate
Formyltetrahydrofolate Synthetase
Ligase, Formate-Tetrahydrofolate
Synthetase, Formyltetrahydrofolate
Tetrahydrofolate Formylase  
Tree Number:   D08.811.464.259.550
Definition English:   A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity. 
See Related English:   Methenyltetrahydrofolate Cyclohydrolase
Methylenetetrahydrofolate Dehydrogenase (NADP)
 
History Note English:   98(75) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   5709 
Unique Identifier:   D005574 

Occurrence in VHL:
 

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